Distinct Classes of Proteasome-Modulating Agents Cooperatively Augment Recombinant Adeno-Associated Virus Type 2 and Type 5-Mediated Transduction from the Apical Surfaces of Human Airway Epithelia

Tripeptidyl aldehyde proteasome inhibitors have been shown to effectively increase viral capsid ubiquitination and transduction of recombinant adeno-associated virus type 2 (rAAV-2) and rAAV-5 serotypes. In the present study we have characterized a second class of proteasome-modulating agents (anthr...

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Detalhes bibliográficos
Main Authors: Yan, Ziying, Zak, Roman, Zhang, Yulong, Ding, Wei, Godwin, Simon, Munson, Keith, Peluso, Richard, Engelhardt, John F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Gene Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC353734/
https://ncbi.nlm.nih.gov/pubmed/14990705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.6.2863-2874.2004
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