Distinct Transduction Difference Between Adeno-Associated Virus Type 1 and Type 6 Vectors in Human Polarized Airway Epithelia

Of the many biologically isolated AAV serotypes, AAV1 and AAV6 share the highest degree of sequence homology, with only six different capsid residues. We compared the transduction efficiencies of rAAV1 and rAAV6 in primary polarized human airway epithelia (HAE) and found significant differences in t...

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Hauptverfasser: Yan, Ziying, Lei-Butters, Diana Chi Man, Keiser, Nicholas W., Engelhardt, John F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3443503/
https://ncbi.nlm.nih.gov/pubmed/22695783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2012.46
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