Second-Strand Genome Conversion of Adeno-Associated Virus Type 2 (AAV-2) and AAV-5 Is Not Rate Limiting following Apical Infection of Polarized Human Airway Epithelia

Recombinant adeno-associated virus type 5 (rAAV-5) is known to efficiently transduce airway epithelia via apical infection. In contrast, rAAV-2 has been shown to be inherently ineffective at transducing airway epithelia from the apical surface. However, tripeptide proteasome inhibitors (such as LLnL...

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Detalhes bibliográficos
Main Authors: Ding, Wei, Yan, Ziying, Zak, Roman, Saavedra, Milene, Rodman, David M., Engelhardt, John F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Gene Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC164830/
https://ncbi.nlm.nih.gov/pubmed/12805434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.13.7361-7366.2003
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