Adeno-Associated Virus Type 5 (AAV5) but Not AAV2 Binds to the Apical Surfaces of Airway Epithelia and Facilitates Gene Transfer

In the genetic disease cystic fibrosis, recombinant adeno-associated virus type 2 (AAV2) is being investigated as a vector to transfer CFTR cDNA to airway epithelia. However, earlier work has shown that the apical surface of human airway epithelia is resistant to infection by AAV2, presumably as a r...

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מידע ביבליוגרפי
Main Authors: Zabner, Joseph, Seiler, Michael, Walters, Robert, Kotin, Robert M., Fulgeras, Wendy, Davidson, Beverly L., Chiorini, John A.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2000
נושאים:
Gene Therapy
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC111893/
https://ncbi.nlm.nih.gov/pubmed/10729159
תגים: הוספת תג
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