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Adeno-Associated Virus Type 5 (AAV5) but Not AAV2 Binds to the Apical Surfaces of Airway Epithelia and Facilitates Gene Transfer

In the genetic disease cystic fibrosis, recombinant adeno-associated virus type 2 (AAV2) is being investigated as a vector to transfer CFTR cDNA to airway epithelia. However, earlier work has shown that the apical surface of human airway epithelia is resistant to infection by AAV2, presumably as a r...

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Udgivet i:J Virol
Principais autores: Zabner, Joseph, Seiler, Michael, Walters, Robert, Kotin, Robert M., Fulgeras, Wendy, Davidson, Beverly L., Chiorini, John A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2000
Fag:
Gene Therapy
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC111893/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10729159/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.8.3852-3858.2000
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