Deep-sequencing approach for minimal residual disease detection in acute lymphoblastic leukemia

The persistence of minimal residual disease (MRD) during therapy is the strongest adverse prognostic factor in acute lymphoblastic leukemia (ALL). We developed a high-throughput sequencing method that universally amplifies antigen-receptor gene segments and identifies all clonal gene rearrangements...

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Autori principali: Faham, Malek, Zheng, Jianbiao, Moorhead, Martin, Carlton, Victoria E. H., Stow, Patricia, Coustan-Smith, Elaine, Pui, Ching-Hon, Campana, Dario
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2012
Soggetti:
Clinical Trials and Observations
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537310/
https://ncbi.nlm.nih.gov/pubmed/23074282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-07-444042
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