Deep-sequencing approach for minimal residual disease detection in acute lymphoblastic leukemia

The persistence of minimal residual disease (MRD) during therapy is the strongest adverse prognostic factor in acute lymphoblastic leukemia (ALL). We developed a high-throughput sequencing method that universally amplifies antigen-receptor gene segments and identifies all clonal gene rearrangements...

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Autors principals: Faham, Malek, Zheng, Jianbiao, Moorhead, Martin, Carlton, Victoria E. H., Stow, Patricia, Coustan-Smith, Elaine, Pui, Ching-Hon, Campana, Dario
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2012
Matèries:
Clinical Trials and Observations
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537310/
https://ncbi.nlm.nih.gov/pubmed/23074282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-07-444042
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