Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration

Although phosphatidylinositol 5-phosphate (PtdIns5P) is present in many cell types and its biogenesis is increased by diverse stimuli, its precise cellular function remains elusive. Here we show that PtdIns5P levels increase when cells are stimulated to move and we find PtdIns5P to promote cell migr...

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Bibliografiska uppgifter
Huvudupphovsmän: Oppelt, Angela, Lobert, Viola H, Haglund, Kaisa, Mackey, Ashley M, Rameh, Lucia E, Liestøl, Knut, Oliver Schink, Kay, Marie Pedersen, Nina, Wenzel, Eva M, Haugsten, Ellen M, Brech, Andreas, Erik Rusten, Tor, Stenmark, Harald, Wesche, Jørgen
Materialtyp: Artigo
Språk:Inglês
Publicerad: European Molecular Biology Organization 2013
Ämnen:
Scientific Reports
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537138/
https://ncbi.nlm.nih.gov/pubmed/23154468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2012.183
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