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AKT Facilitates EGFR Trafficking and Degradation by Phosphorylating and Activating PIKfyve

Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that controls cell proliferation, growth, survival, metabolism, and migration by activating the PI3K (phosphoinositide 3-kinase)-AKT and ERK (extracellular signal regulated kinase)-RSK (ribosomal S6 kinase) pathways. EGFR signalin...

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Detalhes bibliográficos
Main Authors: Emrah Er, E, Mendoza, Michelle C., Mackey, Ashley M., Rameh, Lucia E., Blenis, John
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041878/
https://ncbi.nlm.nih.gov/pubmed/23757022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2004015
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