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AKT Facilitates EGFR Trafficking and Degradation by Phosphorylating and Activating PIKfyve
Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that controls cell proliferation, growth, survival, metabolism, and migration by activating the PI3K (phosphoinositide 3-kinase)-AKT and ERK (extracellular signal regulated kinase)-RSK (ribosomal S6 kinase) pathways. EGFR signalin...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4041878/ https://ncbi.nlm.nih.gov/pubmed/23757022 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2004015 |
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