Directed Evolution of a Model Primordial Enzyme Provides Insights into the Development of the Genetic Code

The contemporary proteinogenic repertoire contains 20 amino acids with diverse functional groups and side chain geometries. Primordial proteins, in contrast, were presumably constructed from a subset of these building blocks. Subsequent expansion of the proteinogenic alphabet would have enhanced the...

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Detalhes bibliográficos
Main Authors: Müller, Manuel M., Allison, Jane R., Hongdilokkul, Narupat, Gaillon, Laurent, Kast, Peter, van Gunsteren, Wilfred F., Marlière, Philippe, Hilvert, Donald
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536711/
https://ncbi.nlm.nih.gov/pubmed/23300488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003187
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