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Attenuation of Semliki Forest Virus Neurovirulence by MicroRNA-Mediated Detargeting

Artificial target sequences for tissue-specific miRNAs have recently been introduced as a new means for altering the tissue tropism of viral replication. This approach can be used to improve the safety of oncolytic viruses for cancer virotherapy by restricting their replication in unwanted tissues,...

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Detalhes bibliográficos
Main Authors: Ylösmäki, Erkko, Martikainen, Miika, Hinkkanen, Ari, Saksela, Kalle
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536368/
https://ncbi.nlm.nih.gov/pubmed/23077310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01940-12
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