Cadherin-11 regulates cell-cell tension necessary for calcific nodule formation by valvular myofibroblasts

OBJECTIVE: Dystrophic calcific nodule formation in vitro involves differentiation of aortic valve interstitial cells (AVICs) into a myofibroblast phenotype. Interestingly, inhibition of the kinase MEK1/2 prevents calcific nodule formation despite leading to myofibroblast activation of AVICs, indicat...

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Huvudupphovsmän: Hutcheson, Joshua D., Chen, Joseph, Sewell-Loftin, M.K., Ryzhova, Larisa M., Fisher, Charles I., Su, Yan Ru, Merryman, W. David
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536033/
https://ncbi.nlm.nih.gov/pubmed/23162011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.112.300278
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