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5-HT(2B) antagonism arrests non-canonical TGF-β1-induced valvular myofibroblast differentiation
Transforming growth factor-β1 (TGF-β1) induces myofibroblast activation of quiescent aortic valve interstitial cells (AVICs), a differentiation process implicated in calcific aortic valve disease (CAVD). The ubiquity of TGF-β1 signaling makes it difficult to target in a tissue specific manner; howev...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3472096/ https://ncbi.nlm.nih.gov/pubmed/22940605 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2012.08.012 |
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