Notch1 mutation leads to valvular calcification through enhanced myofibroblast mechanotransduction

OBJECTIVE: Calcific aortic valve disease (CAVD) is a significant cardiovascular disorder, and controversy exists as to whether it is primarily a dystrophic or osteogenic process in vivo. In this study, we sought to clarify the mechanism of CAVD by assessing a genetic mutation, Notch1 heterozygosity,...

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Veröffentlicht in:Arterioscler Thromb Vasc Biol
Hauptverfasser: Chen, Joseph, Ryzhova, Larisa M., Sewell-Loftin, M.K., Brown, Christopher B., Huppert, Stacey S., Baldwin, H. Scott, Merryman, W. David
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4600070/
https://ncbi.nlm.nih.gov/pubmed/26023079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.114.305095
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