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Notch1 mutation leads to valvular calcification through enhanced myofibroblast mechanotransduction
OBJECTIVE: Calcific aortic valve disease (CAVD) is a significant cardiovascular disorder, and controversy exists as to whether it is primarily a dystrophic or osteogenic process in vivo. In this study, we sought to clarify the mechanism of CAVD by assessing a genetic mutation, Notch1 heterozygosity,...
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| Publicado no: | Arterioscler Thromb Vasc Biol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4600070/ https://ncbi.nlm.nih.gov/pubmed/26023079 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.114.305095 |
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