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Cadherin-11 regulates cell-cell tension necessary for calcific nodule formation by valvular myofibroblasts
OBJECTIVE: Dystrophic calcific nodule formation in vitro involves differentiation of aortic valve interstitial cells (AVICs) into a myofibroblast phenotype. Interestingly, inhibition of the kinase MEK1/2 prevents calcific nodule formation despite leading to myofibroblast activation of AVICs, indicat...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3536033/ https://ncbi.nlm.nih.gov/pubmed/23162011 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.112.300278 |
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