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Multiple tyrosine residues at the GABA binding pocket influence surface expression and mediate kinetics of the GABA(A) receptor
The prevalence of aromatic residues in the ligand binding site of the GABA(A) receptor, as with other cys-loop ligand-gated ion channels, is undoubtedly important for the ability of neurotransmitters to bind and trigger channel opening. Here we have examined three conserved tyrosine residues at the...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3535540/ https://ncbi.nlm.nih.gov/pubmed/23121119 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.12083 |
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