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Tyrosine Residue in the TRPV1 Vanilloid Binding Pocket Regulates Deactivation Kinetics
Vanilloids are pain evoking molecules that serve as ligands of the “heat and capsaicin receptor” TRPV1. Binding of either endogenous or exogenous vanilloids evokes channel and subsequent neuronal activation, leading to pain sensation. Despite its pivotal physiological role, the molecular basis of TR...
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| Опубликовано в: : | J Biol Chem |
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| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4919467/ https://ncbi.nlm.nih.gov/pubmed/27143360 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.726372 |
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