Carvedilol Analogue Inhibits Triggered Activities Evoked by Both Early and Delayed Afterdepolarizations

BACKGROUND: Carvedilol and its analogues suppress delayed afterdepolarizations (DADs) and catecholaminergic polymorphic ventricular tachycardias by direct action on the cardiac ryanodine receptor (RyR2). OBJECTIVE: We tested a hypothesis that carvedilol analogue may also prevent triggered activities...

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Main Authors: Maruyama, Mitsunori, Xiao, Jianmin, Zhou, Qiang, Vembaiyan, Kannan, Chua, Su-Kiat, Rubart-von der Lohe, Michael, Lin, Shien-Fong, Back, Thomas G., Chen, SR Wayne, Chen, Peng-Sheng
Format: Artigo
Language:Inglês
Published: 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3534812/
https://ncbi.nlm.nih.gov/pubmed/22982970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2012.09.006
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