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Novel Carvedilol Analogs that Suppress Store Overload Induced Ca(2+) Release
Carvedilol is a uniquely effective drug for the treatment of cardiac arrhythmias in patients with heart failure. This activity is in part due to its ability to inhibit store overload-induced calcium release (SOICR) through the RyR2 channel. We describe the synthesis, characterization and bioassay of...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3896386/ https://ncbi.nlm.nih.gov/pubmed/24124794 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401090a |
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