Novel Carvedilol Analogs that Suppress Store Overload Induced Ca(2+) Release

Carvedilol is a uniquely effective drug for the treatment of cardiac arrhythmias in patients with heart failure. This activity is in part due to its ability to inhibit store overload-induced calcium release (SOICR) through the RyR2 channel. We describe the synthesis, characterization and bioassay of...

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Huvudupphovsmän: Smith, Chris D., Wang, Aixia, Vembaiyan, Kannan, Zhang, Jingqun, Xie, Cuihong, Zhou, Qiang, Wu, Guogen, Wayne Chen, S. R., Back, Thomas G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3896386/
https://ncbi.nlm.nih.gov/pubmed/24124794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401090a
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