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Carvedilol inhibits cADPR- and IP(3)-induced Ca(2+) release
Spontaneous Ca(2+) waves, also termed store-overload-induced Ca(2+) release (SOICR), in cardiac cells can trigger ventricular arrhythmias especially in failing hearts. SOICR occurs when RyRs are activated by an increase in sarcoplasmic reticulum (SR) luminal Ca(2+). Carvedilol is one of the most eff...
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| Publicado no: | Messenger (Los Angel) |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5531262/ https://ncbi.nlm.nih.gov/pubmed/28758053 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1166/msr.2016.1050 |
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