Carvedilol inhibits cADPR- and IP(3)-induced Ca(2+) release

Spontaneous Ca(2+) waves, also termed store-overload-induced Ca(2+) release (SOICR), in cardiac cells can trigger ventricular arrhythmias especially in failing hearts. SOICR occurs when RyRs are activated by an increase in sarcoplasmic reticulum (SR) luminal Ca(2+). Carvedilol is one of the most eff...

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Bibliografiska uppgifter
I publikationen:Messenger (Los Angel)
Huvudupphovsmän: Morgan, Anthony J., Bampali, Konstantina, Ruas, Margarida, Factor, Cailley, Back, Thomas G., Chen, S.R. Wayne, Galione, Antony
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5531262/
https://ncbi.nlm.nih.gov/pubmed/28758053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1166/msr.2016.1050
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