Carvedilol Analogue Modulates both Basal and Stimulated Sinoatrial Node Automaticity

BACKGROUND: The membrane voltage clock and calcium (Ca(2+)) clock jointly regulate sinoatrial node (SAN) automaticity. VK-II-36 is a novel carvedilol analog that suppress sarcoplasmic reticulum (SR) Ca(2+) release but does not block β-receptor. The effect of VK-II-36 on SAN function remains unclear....

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Shinohara, Tetsuji, Kim, Daehyeok, Joung, Boyoung, Maruyama, Mitsunori, Vembaiyan, Kannan, Back, Thomas G., Chen, S.R. Wayne, Chen, Peng-Sheng, Lin, Shien-Fong
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2013
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3849120/
https://ncbi.nlm.nih.gov/pubmed/23836067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00380-013-0378-2
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