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Carvedilol Analogue Modulates both Basal and Stimulated Sinoatrial Node Automaticity
BACKGROUND: The membrane voltage clock and calcium (Ca(2+)) clock jointly regulate sinoatrial node (SAN) automaticity. VK-II-36 is a novel carvedilol analog that suppress sarcoplasmic reticulum (SR) Ca(2+) release but does not block β-receptor. The effect of VK-II-36 on SAN function remains unclear....
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3849120/ https://ncbi.nlm.nih.gov/pubmed/23836067 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00380-013-0378-2 |
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