TRAIL conjugated to nanoparticles exhibits increased anti-tumor activities in glioma cells and glioma stem cells in vitro and in vivo

Glioblastomas (GBM) are characterized by resistance to chemotherapy and radiotherapy, and therefore, alternative therapeutic approaches are needed. TRAIL induces apoptosis in cancer but not in normal cells and is considered to be a promising anti-tumor agent. However, its short in vivo half-life and...

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Detalles Bibliográficos
Main Authors: Perlstein, Benny, Finniss, Susan A., Miller, Cathie, Okhrimenko, Hana, Kazimirsky, Gila, Cazacu, Simona, Lee, Hae Kyung, Lemke, Nancy, Brodie, Shlomit, Umansky, Felix, Rempel, Sandra A., Rosenblum, Mark, Mikklesen, Tom, Margel, Shlomo, Brodie, Chaya
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2013
Assuntos:
Basic and Translational Investigations
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3534416/
https://ncbi.nlm.nih.gov/pubmed/23144078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nos248
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