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Cilengitide induces autophagy-mediated cell death in glioma cells

We studied the effect of the integrin inhibitor cilengitide in glioma cells. Cilengitide induced cell detachment and decreased cell viability, and induction of autophagy followed by cell apoptosis. In addition, cilengitide decreased the cell renewal of glioma stem-like cells (GSCs). Inhibition of au...

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Autors principals: Lomonaco, Stephanie L., Finniss, Susan, Xiang, Cunli, Lee, Hae Kyung, Jiang, Wei, Lemke, Nancy, Rempel, Sandra A., Mikkelsen, Tom, Brodie, Chaya
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3145473/
https://ncbi.nlm.nih.gov/pubmed/21788343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nor073
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