Cilengitide induces autophagy-mediated cell death in glioma cells

We studied the effect of the integrin inhibitor cilengitide in glioma cells. Cilengitide induced cell detachment and decreased cell viability, and induction of autophagy followed by cell apoptosis. In addition, cilengitide decreased the cell renewal of glioma stem-like cells (GSCs). Inhibition of au...

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Detalhes bibliográficos
Main Authors: Lomonaco, Stephanie L., Finniss, Susan, Xiang, Cunli, Lee, Hae Kyung, Jiang, Wei, Lemke, Nancy, Rempel, Sandra A., Mikkelsen, Tom, Brodie, Chaya
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3145473/
https://ncbi.nlm.nih.gov/pubmed/21788343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nor073
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