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Repurposing phenformin for the targeting of glioma stem cells and the treatment of glioblastoma
Glioblastoma (GBM) is the most aggressive primary brain tumor with poor prognosis. Here, we studied the effects of phenformin, a mitochondrial complex I inhibitor and more potent chemical analog of the diabetes drug metformin on the inhibition of cell growth and induction of apoptosis of glioma stem...
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| Publié dans: | Oncotarget |
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| Auteurs principaux: | , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Impact Journals LLC
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5302927/ https://ncbi.nlm.nih.gov/pubmed/27486821 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10919 |
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