Repurposing phenformin for the targeting of glioma stem cells and the treatment of glioblastoma

Glioblastoma (GBM) is the most aggressive primary brain tumor with poor prognosis. Here, we studied the effects of phenformin, a mitochondrial complex I inhibitor and more potent chemical analog of the diabetes drug metformin on the inhibition of cell growth and induction of apoptosis of glioma stem...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Jiang, Wei, Finniss, Susan, Cazacu, Simona, Xiang, Cunli, Brodie, Ziv, Mikkelsen, Tom, Poisson, Laila, Shackelford, David B., Brodie, Chaya
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5302927/
https://ncbi.nlm.nih.gov/pubmed/27486821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10919
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