Repurposing phenformin for the targeting of glioma stem cells and the treatment of glioblastoma

Glioblastoma (GBM) is the most aggressive primary brain tumor with poor prognosis. Here, we studied the effects of phenformin, a mitochondrial complex I inhibitor and more potent chemical analog of the diabetes drug metformin on the inhibition of cell growth and induction of apoptosis of glioma stem...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Jiang, Wei, Finniss, Susan, Cazacu, Simona, Xiang, Cunli, Brodie, Ziv, Mikkelsen, Tom, Poisson, Laila, Shackelford, David B., Brodie, Chaya
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5302927/
https://ncbi.nlm.nih.gov/pubmed/27486821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10919
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