Accurate variant detection across non-amplified and whole genome amplified DNA using targeted next generation sequencing

BACKGROUND: Many hypothesis-driven genetic studies require the ability to comprehensively and efficiently target specific regions of the genome to detect sequence variations. Often, sample availability is limited requiring the use of whole genome amplification (WGA). We evaluated a high-throughput m...

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Hauptverfasser: ElSharawy, Abdou, Warner, Jason, Olson, Jeff, Forster, Michael, Schilhabel, Markus B, Link, Darren R, Rose-John, Stefan, Schreiber, Stefan, Rosenstiel, Philip, Brayer, James, Franke, Andre
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2012
Schlagworte:
Methodology Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3534403/
https://ncbi.nlm.nih.gov/pubmed/22994565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-13-500
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