Accurate variant detection across non-amplified and whole genome amplified DNA using targeted next generation sequencing

BACKGROUND: Many hypothesis-driven genetic studies require the ability to comprehensively and efficiently target specific regions of the genome to detect sequence variations. Often, sample availability is limited requiring the use of whole genome amplification (WGA). We evaluated a high-throughput m...

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Hlavní autoři: ElSharawy, Abdou, Warner, Jason, Olson, Jeff, Forster, Michael, Schilhabel, Markus B, Link, Darren R, Rose-John, Stefan, Schreiber, Stefan, Rosenstiel, Philip, Brayer, James, Franke, Andre
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2012
Témata:
Methodology Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3534403/
https://ncbi.nlm.nih.gov/pubmed/22994565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-13-500
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