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γ-Secretase Modulators: Can We Combine Potency with Safety?
γ-Secretase modulation has been proposed as a potential disease modifying anti-Alzheimer's approach. γ-Secretase modulators (GSMs) cause a product shift from the longer amyloid-beta (Aβ) peptide isoforms to shorter, more soluble, and less amyloidogenic isoforms, without inhibiting APP or Notch...
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| Autors principals: | , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Hindawi Publishing Corporation
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3534213/ https://ncbi.nlm.nih.gov/pubmed/23365783 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/295207 |
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