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Src-Like Adaptor Protein (SLAP) Binds to the Receptor Tyrosine Kinase Flt3 and Modulates Receptor Stability and Downstream Signaling

Fms-like tyrosine kinase 3 (Flt3) is an important growth factor receptor in hematopoiesis. Gain-of-function mutations of the receptor contribute to the transformation of acute myeloid leukemia (AML). Src-like adaptor protein (SLAP) is an interaction partner of the E3 ubiquitin ligase Cbl that can re...

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Bibliografische gegevens
Hoofdauteurs: Kazi, Julhash U., Rönnstrand, Lars
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2012
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3534055/
https://ncbi.nlm.nih.gov/pubmed/23300935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0053509
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