Engineering HIV-1-Resistant T-Cells from Short-Hairpin RNA-Expressing Hematopoietic Stem/Progenitor Cells in Humanized BLT Mice

Down-regulation of the HIV-1 coreceptor CCR5 holds significant potential for long-term protection against HIV-1 in patients. Using the humanized bone marrow/liver/thymus (hu-BLT) mouse model which allows investigation of human hematopoietic stem/progenitor cell (HSPC) transplant and immune system re...

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Main Authors: Ringpis, Gene-Errol E., Shimizu, Saki, Arokium, Hubert, Camba-Colón, Joanna, Carroll, Maria V., Cortado, Ruth, Xie, Yiming, Kim, Patrick Y., Sahakyan, Anna, Lowe, Emily L., Narukawa, Munetoshi, Kandarian, Fadi N., Burke, Bryan P., Symonds, Geoff P., An, Dong Sung, Chen, Irvin S. Y., Kamata, Masakazu
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3534037/
https://ncbi.nlm.nih.gov/pubmed/23300932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0053492
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