Engineering HIV-1-Resistant T-Cells from Short-Hairpin RNA-Expressing Hematopoietic Stem/Progenitor Cells in Humanized BLT Mice

Down-regulation of the HIV-1 coreceptor CCR5 holds significant potential for long-term protection against HIV-1 in patients. Using the humanized bone marrow/liver/thymus (hu-BLT) mouse model which allows investigation of human hematopoietic stem/progenitor cell (HSPC) transplant and immune system re...

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Bibliographic Details
Main Authors: Ringpis, Gene-Errol E., Shimizu, Saki, Arokium, Hubert, Camba-Colón, Joanna, Carroll, Maria V., Cortado, Ruth, Xie, Yiming, Kim, Patrick Y., Sahakyan, Anna, Lowe, Emily L., Narukawa, Munetoshi, Kandarian, Fadi N., Burke, Bryan P., Symonds, Geoff P., An, Dong Sung, Chen, Irvin S. Y., Kamata, Masakazu
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3534037/
https://ncbi.nlm.nih.gov/pubmed/23300932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0053492
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