RNAi-Mediated CCR5 Knockdown Provides HIV-1 Resistance to Memory T Cells in Humanized BLT Mice

Transplantation of hematopoietic stem/progenitor cells (HSPC) modified with a lentiviral vector bearing a potent nontoxic short hairpin RNA (sh1005) directed to the HIV coreceptor CCR5 is capable of continuously producing CCR5 downregulated CD4+ T lymphocytes. Here, we characterized HIV-1 resistance...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: Shimizu, Saki, Ringpis, Gene-Errol, Marsden, Matthew D, Cortado, Ruth V, Wilhalme, Holly M, Elashoff, David, Zack, Jerome A, Chen, Irvin S Y, An, Dong Sung
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4345313/
https://ncbi.nlm.nih.gov/pubmed/25689223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2015.3
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