A highly efficient short hairpin RNA potently down-regulates CCR5 expression in systemic lymphoid organs in the hu-BLT mouse model

Inhibiting the expression of the HIV-1 coreceptor CCR5 holds great promise for controlling HIV-1 infection in patients. Here we report stable knockdown of human CCR5 by a short hairpin RNA (shRNA) in a humanized bone marrow/liver/thymus (BLT) mouse model. We delivered a potent shRNA against CCR5 int...

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Detalhes bibliográficos
Main Authors: Shimizu, Saki, Hong, Patrick, Arumugam, Balamurugan, Pokomo, Lauren, Boyer, Joshua, Koizumi, Naoya, Kittipongdaja, Panyamol, Chen, Angela, Bristol, Greg, Galic, Zoran, Zack, Jerome A., Yang, Otto, Chen, Irvin S. Y., Lee, Benhur, An, Dong Sung
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Gene Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830759/
https://ncbi.nlm.nih.gov/pubmed/20018916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-04-215855
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