Generation and Characterization of a Novel Cyp2a(4/5)bgs-Null Mouse Model

Knockout mouse models targeting various cytochrome P450 (P450 or CYP) genes are valuable for determining P450’s biologic functions, including roles in drug metabolism and chemical toxicity. In this study, a novel Cyp2a(4/5)bgs-null mouse model was generated, in which a 1.2-megabase pair genomic frag...

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Hlavní autoři: Wei, Yuan, Li, Lei, Zhou, Xin, Zhang, Qing-Yu, Dunbar, Anwar, Liu, Fang, Kluetzman, Kerri, Yang, Weizhu, Ding, Xinxin
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533424/
https://ncbi.nlm.nih.gov/pubmed/23073733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.112.048736
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