Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors

Despite efforts to understand and treat acute myeloid leukemia (AML), there remains a need for more comprehensive therapies to prevent AML-associated relapses. To identify new therapeutic strategies for AML, we screened a library of on- and off-patent drugs and identified the antimalarial agent mefl...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Sukhai, Mahadeo A., Prabha, Swayam, Hurren, Rose, Rutledge, Angela C., Lee, Anna Y., Sriskanthadevan, Shrivani, Sun, Hong, Wang, Xiaoming, Skrtic, Marko, Seneviratne, Ayesh, Cusimano, Maria, Jhas, Bozhena, Gronda, Marcela, MacLean, Neil, Cho, Eunice E., Spagnuolo, Paul A., Sharmeen, Sumaiya, Gebbia, Marinella, Urbanus, Malene, Eppert, Kolja, Dissanayake, Dilan, Jonet, Alexia, Dassonville-Klimpt, Alexandra, Li, Xiaoming, Datti, Alessandro, Ohashi, Pamela S., Wrana, Jeff, Rogers, Ian, Sonnet, Pascal, Ellis, William Y., Corey, Seth J., Eaves, Connie, Minden, Mark D., Wang, Jean C.Y., Dick, John E., Nislow, Corey, Giaever, Guri, Schimmer, Aaron D.
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Clinical Investigation 2012
الموضوعات:
Research Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533286/
https://ncbi.nlm.nih.gov/pubmed/23202731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI64180
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