Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors

Despite efforts to understand and treat acute myeloid leukemia (AML), there remains a need for more comprehensive therapies to prevent AML-associated relapses. To identify new therapeutic strategies for AML, we screened a library of on- and off-patent drugs and identified the antimalarial agent mefl...

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Hlavní autoři: Sukhai, Mahadeo A., Prabha, Swayam, Hurren, Rose, Rutledge, Angela C., Lee, Anna Y., Sriskanthadevan, Shrivani, Sun, Hong, Wang, Xiaoming, Skrtic, Marko, Seneviratne, Ayesh, Cusimano, Maria, Jhas, Bozhena, Gronda, Marcela, MacLean, Neil, Cho, Eunice E., Spagnuolo, Paul A., Sharmeen, Sumaiya, Gebbia, Marinella, Urbanus, Malene, Eppert, Kolja, Dissanayake, Dilan, Jonet, Alexia, Dassonville-Klimpt, Alexandra, Li, Xiaoming, Datti, Alessandro, Ohashi, Pamela S., Wrana, Jeff, Rogers, Ian, Sonnet, Pascal, Ellis, William Y., Corey, Seth J., Eaves, Connie, Minden, Mark D., Wang, Jean C.Y., Dick, John E., Nislow, Corey, Giaever, Guri, Schimmer, Aaron D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2012
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533286/
https://ncbi.nlm.nih.gov/pubmed/23202731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI64180
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