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Conservation of Flexible Residue Clusters among Structural and Functional Enzyme Homologues

Conformational flexibility between structural ensembles is an essential component of enzyme function. Although the broad dynamical landscape of proteins is known to promote a number of functional events on multiple time scales, it is yet unknown whether structural and functional enzyme homologues re...

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Main Authors: Gagné, Donald, Charest, Laurie-Anne, Morin, Sébastien, Kovrigin, Evgenii L., Doucet, Nicolas
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3531744/
https://ncbi.nlm.nih.gov/pubmed/23135272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.394866
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