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Impaired suppressive activities of human MUTYH variant proteins against oxidative mutagenesis

AIM: To investigate the suppressive activity of MUTYH variant proteins against mutations caused by oxidative lesion, 8-hydroxyguanine (8OHG), in human cells. METHODS: p.R154H, p.M255V, p.L360P, and p.P377L MUTYH variants, which were previously found in patients with colorectal polyposis and cancer,...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Shinmura, Kazuya, Goto, Masanori, Tao, Hong, Matsuura, Shun, Matsuda, Tomonari, Sugimura, Haruhiko
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Baishideng Publishing Group Co., Limited 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3531677/
https://ncbi.nlm.nih.gov/pubmed/23322991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v18.i47.6935
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