Adenine DNA Glycosylase Activity of 14 Human MutY Homolog (MUTYH) Variant Proteins Found in Patients with Colorectal Polyposis and Cancer

Biallelic inactivating germline mutations in the base excision repair MUTYH (MYH) gene have been shown to predispose to MUTYH-associated polyposis (MAP), which is characterized by multiple colorectal adenomas and carcinomas. In this study, we successfully prepared highly homogeneous human MUTYH type...

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Bibliografiske detaljer
Main Authors: Goto, Masanori, Shinmura, Kazuya, Nakabeppu, Yusaku, Tao, Hong, Yamada, Hidetaka, Tsuneyoshi, Toshihiro, Sugimura, Haruhiko
Format: Artigo
Sprog:Inglês
Udgivet: Wiley Subscription Services, Inc., A Wiley Company 2010
Fag:
Mutation in Brief
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3051265/
https://ncbi.nlm.nih.gov/pubmed/20848659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/humu.21363
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