Structure of the mammalian adenine DNA glycosylase MUTYH: insights into the base excision repair pathway and cancer

Mammalian MutY homologue (MUTYH) is an adenine DNA glycosylase that excises adenine inserted opposite 8-oxoguanine (8-oxoG). The inherited variations in human MUTYH gene are known to cause MUTYH-associated polyposis (MAP), which is associated with colorectal cancer. MUTYH is involved in base excisio...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Nakamura, Teruya, Okabe, Kohtaro, Hirayama, Shogo, Chirifu, Mami, Ikemizu, Shinji, Morioka, Hiroshi, Nakabeppu, Yusaku, Yamagata, Yuriko
Format: Artigo
Language:Inglês
Published: Oxford University Press 2021
Subjects:
Structural Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8266592/
https://ncbi.nlm.nih.gov/pubmed/34142156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab492
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