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Structure of the mammalian adenine DNA glycosylase MUTYH: insights into the base excision repair pathway and cancer
Mammalian MutY homologue (MUTYH) is an adenine DNA glycosylase that excises adenine inserted opposite 8-oxoguanine (8-oxoG). The inherited variations in human MUTYH gene are known to cause MUTYH-associated polyposis (MAP), which is associated with colorectal cancer. MUTYH is involved in base excisio...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8266592/ https://ncbi.nlm.nih.gov/pubmed/34142156 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab492 |
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