Impaired 8-Hydroxyguanine Repair Activity of MUTYH Variant p.Arg109Trp Found in a Japanese Patient with Early-Onset Colorectal Cancer

Purpose. The biallelic inactivation of the 8-hydroxyguanine repair gene MUTYH leads to MUTYH-associated polyposis (MAP), which is characterized by colorectal multiple polyps and carcinoma(s). However, only limited information regarding MAP in the Japanese population is presently available. Since ear...

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Main Authors: Shinmura, Kazuya, Goto, Masanori, Tao, Hong, Kato, Hisami, Suzuki, Rie, Nakamura, Satoki, Matsuda, Tomonari, Yin, Guang, Morita, Makiko, Kono, Suminori, Sugimura, Haruhiko
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3988950/
https://ncbi.nlm.nih.gov/pubmed/24799981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/617351
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