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Impaired suppressive activities of human MUTYH variant proteins against oxidative mutagenesis
AIM: To investigate the suppressive activity of MUTYH variant proteins against mutations caused by oxidative lesion, 8-hydroxyguanine (8OHG), in human cells. METHODS: p.R154H, p.M255V, p.L360P, and p.P377L MUTYH variants, which were previously found in patients with colorectal polyposis and cancer,...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Baishideng Publishing Group Co., Limited
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3531677/ https://ncbi.nlm.nih.gov/pubmed/23322991 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v18.i47.6935 |
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