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In Vitro Evolution Predicts that the IMP-1 Metallo-β-Lactamase Does Not Have the Potential To Evolve Increased Activity against Imipenem
In vitro evolution was used to predict whether the IMP-1 metallo-β-lactamase has the potential to evolve an increased ability to confer resistance to imipenem. Screening of eight libraries containing 9.8 × 10(6) ± 1.4 × 10(6) (mean ± standard error) variants per library, with an average of 1.2 mutat...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2004
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC353146/ https://ncbi.nlm.nih.gov/pubmed/14982802 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.3.1032-1033.2004 |
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