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Novel Bivalent Ligands for D2/D3 Dopamine Receptors: Significant Cooperative Gain in D2 Affinity and Potency
[Image: see text] This report describes development of a series of novel bivalent molecules with a pharmacophore derived from the D2/D3 agonist 5-OH-DPAT. The spacer length in the bivalent compounds had a pronounced influence on affinity for D2 receptors. A 23-fold increase of D2 affinity was observ...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American
Chemical Society
2012
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| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3530844/ https://ncbi.nlm.nih.gov/pubmed/23275802 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml3002117 |
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