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Novel Bivalent Ligands for D2/D3 Dopamine Receptors: Significant Cooperative Gain in D2 Affinity and Potency

[Image: see text] This report describes development of a series of novel bivalent molecules with a pharmacophore derived from the D2/D3 agonist 5-OH-DPAT. The spacer length in the bivalent compounds had a pronounced influence on affinity for D2 receptors. A 23-fold increase of D2 affinity was observ...

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Autores principales: Gogoi, Sanjib, Biswas, Swati, Modi, Gyan, Antonio, Tamara, Reith, Maarten E. A., Dutta, Aloke K.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2012
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3530844/
https://ncbi.nlm.nih.gov/pubmed/23275802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml3002117
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