Structural Modifications of Neuroprotective Anti-Parkinsonian (−)-N6-(2-(4-(Biphenyl-4-yl)piperazin-1-yl)-ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine (D-264): An Effort toward the Improvement of in Vivo Efficacy of the Parent Molecule

Registos relacionados

• Development of (S)-N(6)-(2-(4-(Isoquinolin-1-yl)piperazin-1-yl)ethyl)-N(6)-propyl-4,5,6,7-tetrahydrobenzo[d]-thiazole-2,6-diamine and its analogue as a D3 receptor preferring agonist: Potent in vivo activity in Parkinson’s disease animal models
  Por: Ghosh, Balaram, et al.
  Publicado em: (2010)
• Structure-activity-relationship study of N(6)-(2(4-(1H-indol-5-yl)piperazin-1-yl)ethyl)-N(6)-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine analogues: Development of highly selective D3 dopamine receptor agonists along with a highly potent D2/D3 agonist and their pharmacological characterization
  Por: Johnson, Mark, et al.
  Publicado em: (2012)
• Interaction of D(3) preferring agonist (−)-N(6)-(2-(4-(Biphenyl-4-yl)piperazin-1-yl)ethyl)-N(6)-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine (D-264) with cloned human D(2L), D(2S) and D(3) receptors: Potent stimulation of mitogen-activated protein kinases and G-protein coupled inward rectifier potassium channels
  Por: Kuzhikandathil, Eldo V., et al.
  Publicado em: (2012)
• Efficacy of hybrid tetrahydrobenzo[d]thiazole based aryl piperazines D-264 and D-301 at D(2) and D(3) receptors
  Por: Zhen, Juan, et al.
  Publicado em: (2015)
• Further delineation of hydrophobic binding sites in dopamine D(2)/D(3) receptors for N-4 substituents on the piperazine ring of the hybrid template 5/ 7-{[2-(4-Aryl- piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol
  Por: Ghosh, Balaram, et al.
  Publicado em: (2010)