Development of a Highly Potent D(2)/D(3) Agonist and a Partial Agonist from Structure−Activity Relationship Study of N(6)‑(2-(4-(1H‑Indol-5-yl)piperazin-1-yl)ethyl)‑N(6)‑propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine Analogues: Implication in the Treatment of Parkinson’s Disease

Lignende værker

• Structure-activity-relationship study of N(6)-(2(4-(1H-indol-5-yl)piperazin-1-yl)ethyl)-N(6)-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine analogues: Development of highly selective D3 dopamine receptor agonists along with a highly potent D2/D3 agonist and their pharmacological characterization
  af: Johnson, Mark, et al.
  Udgivet: (2012)
• Structural Modifications of Neuroprotective Anti-Parkinsonian (−)-N6-(2-(4-(Biphenyl-4-yl)piperazin-1-yl)-ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine (D-264): An Effort toward the Improvement of in Vivo Efficacy of the Parent Molecule
  af: Modi, Gyan, et al.
  Udgivet: (2014)
• Development of (S)-N(6)-(2-(4-(Isoquinolin-1-yl)piperazin-1-yl)ethyl)-N(6)-propyl-4,5,6,7-tetrahydrobenzo[d]-thiazole-2,6-diamine and its analogue as a D3 receptor preferring agonist: Potent in vivo activity in Parkinson’s disease animal models
  af: Ghosh, Balaram, et al.
  Udgivet: (2010)
• Interaction of D(3) preferring agonist (−)-N(6)-(2-(4-(Biphenyl-4-yl)piperazin-1-yl)ethyl)-N(6)-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine (D-264) with cloned human D(2L), D(2S) and D(3) receptors: Potent stimulation of mitogen-activated protein kinases and G-protein coupled inward rectifier potassium channels
  af: Kuzhikandathil, Eldo V., et al.
  Udgivet: (2012)
• 4,5,6,7-Tetrahydrobenzo[d]thiazol-2-amine
  af: Fatjonë Krasniqi, et al.
  Udgivet: (2025-10-01)