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Interaction of D(3) preferring agonist (−)-N(6)-(2-(4-(Biphenyl-4-yl)piperazin-1-yl)ethyl)-N(6)-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine (D-264) with cloned human D(2L), D(2S) and D(3) receptors: Potent stimulation of mitogen-activated protein kinases and G-protein coupled inward rectifier potassium channels

PURPOSE: To determine the effect of the novel D(3) dopamine receptor agonist, D-264, on activation of D(3) and D(2) dopamine receptor signal transduction pathways and cell proliferation. METHODS: AtT-20 neuroendocrine cells stably expressing Human D(2S), D(2L) and D(3) dopamine receptors were treate...

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Main Authors: Kuzhikandathil, Eldo V., Cote, Samantha, Santra, Soumava, Dutta, Aloke K.
格式: Artigo
語言:Inglês
出版: 2012
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3560311/
https://ncbi.nlm.nih.gov/pubmed/23160988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00210-012-0811-6
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