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Bivalent phenethylamines as novel dopamine transporter inhibitors: Evidence for multiple substrate-binding sites in a single transporter

Bivalent ligands—compounds incorporating two receptor-interacting moieties linked by a flexible chain—often exhibit profoundly enhanced binding affinity compared to their monovalent components, implying concurrent binding to multiple sites on the target protein. It is generally assumed that neurotra...

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Bibliografische gegevens
Hoofdauteurs: Schmitt, Kyle C, Mamidyala, Sreeman, Biswas, Swati, Dutta, Aloke K, Reith, Maarten EA
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2914574/
https://ncbi.nlm.nih.gov/pubmed/20067583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2010.06583.x
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