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Bivalent phenethylamines as novel dopamine transporter inhibitors: Evidence for multiple substrate-binding sites in a single transporter
Bivalent ligands—compounds incorporating two receptor-interacting moieties linked by a flexible chain—often exhibit profoundly enhanced binding affinity compared to their monovalent components, implying concurrent binding to multiple sites on the target protein. It is generally assumed that neurotra...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2914574/ https://ncbi.nlm.nih.gov/pubmed/20067583 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2010.06583.x |
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