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Multifunctional D2/D3 Agonist D-520 with High in Vivo Efficacy: Modulator of Toxicity of Alpha-Synuclein Aggregates

[Image: see text] We have developed a series of dihydroxy compounds and related analogues based on our hybrid D2/D3 agonist molecular template to develop multifunctional drugs for symptomatic and neuroprotective treatment for Parkinson’s disease (PD). The lead compound (−)-24b (D-520) exhibited high...

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מידע ביבליוגרפי
Main Authors: Modi, Gyan, Voshavar, Chandrashekhar, Gogoi, Sanjib, Shah, Mrudang, Antonio, Tamara, Reith, Maarten E. A., Dutta, Aloke K.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Chemical Society 2014
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140597/
https://ncbi.nlm.nih.gov/pubmed/24960209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn500084x
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