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Multifunctional D2/D3 Agonist D-520 with High in Vivo Efficacy: Modulator of Toxicity of Alpha-Synuclein Aggregates
[Image: see text] We have developed a series of dihydroxy compounds and related analogues based on our hybrid D2/D3 agonist molecular template to develop multifunctional drugs for symptomatic and neuroprotective treatment for Parkinson’s disease (PD). The lead compound (−)-24b (D-520) exhibited high...
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| Main Authors: | , , , , , , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4140597/ https://ncbi.nlm.nih.gov/pubmed/24960209 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn500084x |
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