Cyclin-Dependent Kinase 6 Phosphorylates NF-κB P65 at Serine 536 and Contributes to the Regulation of Inflammatory Gene Expression

Nuclear factor kappa-B (NF-κB) activates multiple genes with overlapping roles in cell proliferation, inflammation and cancer. Using an unbiased approach we identified human CDK6 as a novel kinase phosphorylating NF-κB p65 at serine 536. Purified and reconstituted CDK6/cyclin complexes phosphorylate...

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Detalhes bibliográficos
Main Authors: Buss, Holger, Handschick, Katja, Jurrmann, Nadine, Pekkonen, Pirita, Beuerlein, Knut, Müller, Helmut, Wait, Robin, Saklatvala, Jeremy, Ojala, Päivi M., Schmitz, M. Lienhard, Naumann, Michael, Kracht, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3530474/
https://ncbi.nlm.nih.gov/pubmed/23300567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051847
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